Endocrine Abstracts

Beige adipocytes can be induced from white adipocytes (WAT) and precursors upon stimulation by cold temperatures and act like brown adipocytes (BAT) to increase energy expenditure. Most in vivo studies examining the mechanisms for the induction of beige/brown adipocytes have focused on subcutaneous white adipose tissue (sWAT) in the mouse. To better understand the development of beige/brown adipocytes from mammalian sWAT, we induced WAT and BAT from 3T3-L1 preadipocyt...

Aims: To investigate the mechanism of α-lipoic acid (ALA) on preventing diabetes, we evaluated the effect of ALA on growth regulation and composition of skeletal muscle.Methods: OLETF and LETO rats, aged 24 weeks, were treated with or without ALA (100 mg/kg body weight/day in drinking water) and / or insulin (insulin glargine, 2 U/kg body weight/day; subcutaneous injection) for 8 weeks.Results: The treatment of ALA with or wit...